Pregnant women and minors, patients with extensive skin diseases and people with light allergies; serious heart, liver or blood system, nervous system, malignant tumors, facial nerve pain, hemophilia, pyrexia, as well as patients with epilepsy in response to light sources. If you are taking medicines that may cause light allergy, please follow the doctor's advice to use this equipment with caution, and others who are judged by a doctor or a professional to be incapable of blue, yellow, red or infrared light irradiation.